Evaluation of Prognosis and Related Factors in Children with Solitary Rectal Ulcer Syndrome
| Author | Amirhossein Hosseini | en |
| Author | Maryam Lajmirnia | en |
| Author | Negin Gholizadeh | en |
| Author | Naghi Dara | en |
| Author | Maryam Kazemi Aghdam | en |
| Author | Aliakbar Sayyari | en |
| Author | Farid Imanzadeh | en |
| Author | Negar Imanzadeh | en |
| Author | Mahmoud Hajipour | en |
| Author | Maryam Mollaei | en |
| Orcid | Amirhossein Hosseini [0000-0001-8103-8833] | en |
| Orcid | Negin Gholizadeh [0000-0003-0897-5972] | en |
| Orcid | Naghi Dara [0000-0002-1881-8893] | en |
| Orcid | Maryam Kazemi Aghdam [0000-0001-9948-417X] | en |
| Orcid | Aliakbar Sayyari [0000-0002-2125-7601] | en |
| Orcid | Farid Imanzadeh [0000-0003-0223-6431] | en |
| Orcid | Mahmoud Hajipour [0000-0001-8187-9114] | en |
| Orcid | Maryam Mollaei [0009-0006-7431-4936] | en |
| Issued Date | 2026-05-31 | en |
| Abstract | Background: Solitary Rectal Ulcer Syndrome (SRUS) is a rare disease that commonly manifests in children. Its diagnosis is often delayed due to misdiagnosis with other diseases. Objectives: The aim of this study is to evaluate prognosis and related factors in children. Methods: In this retrospective cohort study, medical records of 101 children with histologically confirmed SRUS were reviewed over a 12-year period (2012 - 2024). Demographic data, clinical presentations, colonoscopic and histopathological findings, treatment modalities, and therapeutic responses were analyzed. Statistical analysis was performed using SPSS, and a P-value ≤0.05 was considered significant. Results: The mean age at diagnosis was 10.46 ± 2.94 years (range: 2.75 - 16.7), and 77.2% were male. The most common presenting symptom was rectal bleeding (89.1%), followed by constipation (73.3%) and abdominal pain (67.3%). Endoscopic findings revealed single ulcers in 53.5% and multiple ulcers in 28.7% of cases. The most frequently prescribed treatments were polyethylene glycol (PEG) (88.1%) and mesalazine (70.3%). After a median follow-up of three years, 68% of patients achieved complete remission with medical management, while 32% experienced recurrence. Rectal bleeding, constipation, digital manipulation, and chronic constipation were significantly associated with relapse (P Conclusions: Findings from colonoscopy and histopathology were helpful in confirming the underlying etiology. Also, multiple follow-ups are required to confirm remission. | en |
| DOI | https://doi.org/10.5812/jcp-166159 | en |
| URI | https://brieflands.com/journals/jcp/articles/166159 | en |
| Keyword | Solitary Rectal Ulcer Syndrome | en |
| Keyword | Rectal Bleeding | en |
| Keyword | Constipation | en |
| Keyword | Abdominal Pain | en |
| Keyword | Children | en |
| Publisher | Brieflands | en |
| Title | Evaluation of Prognosis and Related Factors in Children with Solitary Rectal Ulcer Syndrome | en |
| Type | Research Article | en |
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