Further Stimulation of Cellular Immune Responses through Association of HPV-16 E6, E7 and L1 Genes in order to Produce more Effective Therapeutic DNA Vaccines in Cervical Cancer Model

Abstract

Background: Cervical cancer has been shown to be highly associated with human papillomavirus (HPV) infection. The viral oncogenes E6 and E7 are constantly expressed by the tumor cells and are therefore potent targets for therapeutic genetic vaccination. In the present study, it was investigated the potential effect of HPV-16 E6, E7 and L1 co-administration to activate specific cytotoxic T lymphocytes in tumor mice models.