Synthesis and <i>In-vitro</i> Antibacterial Activities of Acetylanthracene and Acetylphenanthrene Derivatives of Some Fluoroquinolones
| Author | Fazel Shamsa | en |
| Author | Alireza Foroumadi | en |
| Author | Hashim Shamsa | en |
| Author | Nasrin Samadi | en |
| Author | Mohammad Ali Faramarzi | en |
| Author | Abbas Shafiee | en |
| Issued Date | 2011-04-30 | en |
| Abstract | Novel analogues of N-piperazinyl fluoroquinolones were prepared and evaluated against a panel of Gram-positive and Gram-negative bacteria, to study the effect of introducing bulky anthracene and phenanthrene moieties on the antibacterial effects of norfloxacin, ciprofloxacin and gatifloxacin. Although most of the novel synthesized compounds had lower antibacterial effects, some derivatives showed better activity in comparison with mother drugs based on molar concentration; for example, the 3-acetyl phenanthrene analogue of norfloxacin was more effective than E. coli and K. pneumonia. | en |
| DOI | https://doi.org/10.22037/ijpr.2011.972 | en |
| URI | https://brieflands.com/journals/ijpr/articles/125965 | en |
| Keyword | <i>N</i>-substituted piperazinyl quinolones | en |
| Keyword | Anthracene derivatives | en |
| Keyword | Phenanthrene derivatives | en |
| Keyword | <i>In-vitro </i>antibacterial activity | en |
| Publisher | Brieflands | en |
| Title | Synthesis and <i>In-vitro</i> Antibacterial Activities of Acetylanthracene and Acetylphenanthrene Derivatives of Some Fluoroquinolones | en |
| Type | Original Article | en |
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