Investigation of Factors Affecting Aerodynamic Performance of Nebulized Nanoemulsion
| Author | Hosein Kamali | en |
| Author | Shayan Abbasi | en |
| Author | Mohammad Ali Amini | en |
| Author | Amir Amani | en |
| Issued Date | 2016-10-31 | en |
| Abstract | This work aimed to prepare a nanoemulsion preparation containing budesonide and assess its aerodynamic behavior in comparison with suspension of budesonide. In-vitro aerodynamic performance of the corresponding micellar solution (ie. nanoemulsion preparation without oil) was investigated too. Nanoemulsions of almond oil containing budesonide, as a hydrophobic model drug molecule, were prepared and optimized. Then, the effect of variation of surfactant/co-surfactant concentration on the aerodynamic properties of the nebulized aerosol was studied. The results indicated that the most physically stable formulation makes the smallest aerodynamic size. The concentration of co-surfactant was also shown to be critical in determination of aerodynamic size. Furthermore, the optimized sample, with 3% w/w almond oil, 20% w/w Tween 80+Span 80 and 2% w/w ethanol showed a smaller MMAD in comparison with the commercially available suspension and the micellar solution. | en |
| DOI | https://doi.org/10.22037/ijpr.2016.1906 | en |
| Keyword | Nanoemulsion | en |
| Keyword | Micelle | en |
| Keyword | Budesonide | en |
| Keyword | Nebulizer | en |
| Publisher | Brieflands | en |
| Title | Investigation of Factors Affecting Aerodynamic Performance of Nebulized Nanoemulsion | en |
| Type | Original Article | en |
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