Association Between Serum Magnesium Levels and Thrombotic Events in Hospitalized COVID-19 Patients: A Cross-sectional Study
| Author | Abolfazl Khalafinezhad | en |
| Author | Abdorrahim Paak | en |
| Author | Zahra Ghanbarinasab | en |
| Author | Nazanin Alemzadeh | en |
| Author | Vahid Mohammad Karimi | en |
| Orcid | Abolfazl Khalafinezhad [0009-0000-8965-6169] | en |
| Orcid | Abdorrahim Paak [0000-0002-7356-1795] | en |
| Orcid | Zahra Ghanbarinasab [0009-0000-8965-6169] | en |
| Orcid | Vahid Mohammad Karimi [0000-0002-7356-1795] | en |
| Issued Date | 2026-02-28 | en |
| Abstract | Background: Magnesium, the second most abundant intracellular cation, plays a critical role in numerous biological processes, including vascular homeostasis, platelet function, and coagulation. Several studies have suggested that magnesium deficiency may contribute to thrombotic complications and to increased disease severity in coronavirus disease 2019 (COVID-19). Objectives: This study aimed to evaluate the association between serum magnesium levels and thrombotic events in hospitalized patients with COVID-19. Methods: In this observational cross-sectional study, 227 hospitalized patients with confirmed COVID-19 at Shiraz Faghihi and Namazi hospitals were grouped according to the presence or absence of thrombotic events. Serum magnesium was analyzed as a continuous variable, and factors associated with thrombotic events were evaluated using univariate and multivariable logistic regression analysis. Results: Among 227 patients, 68 (30.0%) developed thrombotic events. Mean serum magnesium was lower in patients with thrombosis than in those without thrombosis (1.82 ± 0.20 vs. 1.93 ± 0.39 mg/dL; P = 0.006). In univariate analysis, each 0.1 mg/dL decrease in serum magnesium was associated with higher odds of thrombotic events (odds ratio [OR] = 1.28, 95% confidence interval [CI]: 1.07 - 1.53; P = 0.007); however, this association was not significant after adjustment for age, serum calcium, D-dimer, fibrinogen, and duration of hospitalization (adjusted OR = 1.14, 95% CI: 0.91 - 1.42; P = 0.259). D-dimer, serum calcium, and duration of hospitalization remained independently associated with thrombotic events. Conclusions: Lower serum magnesium levels were associated with thrombotic events in hospitalized patients with COVID-19. However, this association was attenuated after adjustment for potential confounders, suggesting that serum magnesium may reflect disease severity or coagulation disturbances rather than serve as an independent predictor of thrombosis. | en |
| DOI | https://doi.org/10.5812/archcid-170543 | en |
| URI | https://brieflands.com/journals/archcid/articles/170543 | en |
| Keyword | Venous Thromboembolism | en |
| Keyword | Coronavirus Disease 2019 (COVID-19) | en |
| Keyword | Magnesium–Magnesium Deficiency | en |
| Keyword | Mortality in Critically Ill Patients | en |
| Keyword | Intensive Care Unit | en |
| Keyword | Family Caregiver | en |
| Keyword | Aggression | en |
| Keyword | Healthcare Provider | en |
| Keyword | Hospitalization | en |
| Keyword | Stroke | en |
| Publisher | Brieflands | en |
| Title | Association Between Serum Magnesium Levels and Thrombotic Events in Hospitalized COVID-19 Patients: A Cross-sectional Study | en |
| Type | Research Article | en |
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