Helicobacter pylori’s Evasion of the Immune System Could Establish an Inflammatory Environment That Potentially Induces the Development of Coronary Artery Disease

Abstract

Background: Helicobacter pylori is responsible for one of the most common human infections and is a major risk factor for stomach ulcer disease and gastric cancer. H. pylori infection has been reported to be associated with generation and development of coronary artery disease (CAD). Moreover, diabetic patients positive for H. pylori infection showed a higher prevalence of CAD compared to H. pylori-negative patients. The main association between H. pylori infection and CAD seems to be generation of chronic low-grade inflammation.