Design, Synthesis and Biological Evaluation of4-(Imidazolylmethyl)-2-(4-methylsulfonyl phenyl)-Quinoline Derivatives as Selective COX-2 Inhibitors and <i>In-vitro </i>Anti-breast Cancer Agents
| Author | Razieh Ghodsi | en |
| Author | Ebrahim Azizi | en |
| Author | Afshin Zarghi | en |
| Issued Date | 2016-01-31 | en |
| Abstract | A new group of 4-(Imidazolylmethyl)quinoline derivatives possessing a methylsulfonyl COX-2 pharmacophore at the para position of the C-2 phenyl ring were designed and synthesized as selective COX-2 inhibitors and in-vitroanti breast cancer agents. | en |
| DOI | https://doi.org/10.22037/ijpr.2016.1785 | en |
| Keyword | Quinolines | en |
| Keyword | COX-2 inhibitory | en |
| Keyword | Aromatase inhibitory | en |
| Keyword | Breast cancer | en |
| Publisher | Brieflands | en |
| Title | Design, Synthesis and Biological Evaluation of4-(Imidazolylmethyl)-2-(4-methylsulfonyl phenyl)-Quinoline Derivatives as Selective COX-2 Inhibitors and <i>In-vitro </i>Anti-breast Cancer Agents | en |
| Type | Original Article | en |