Accelerating Effects of Vitamin E Supplementation on Liver Enzyme Normalization in Children with Acute Hepatitis A Infection; a Single-Blinded Clinical Trial
| Author | Iraj Shahramian | en |
| Author | Kaveh Tabrizian | en |
| Author | Mahdi Afshari | en |
| Author | Ali Bazi | en |
| Author | Elaheh Bahmadisani | en |
| Orcid | Iraj Shahramian [0000-0002-4134-1405] | en |
| Orcid | Ali Bazi [0000-0003-4872-1352] | en |
| Issued Date | 2020-12-31 | en |
| Abstract | Background: Hepatitis A virus (HAV) infection is a widespread disease with no specific treatment. Objectives: In the present study, we investigated the effects of vitamin E in the treatment of acute HAV infection in children. Methods: This clinical trial study was conducted on 142 patients with acute HAV infection referred to Amir-Al-Momenin Hospital of Zabol during February 2016-August 2017. The patients were randomly divided into two groups of intervention (Vit E, n = 71) and control (no medication, n = 71). Liver enzymes were monitored during a six-month period. Results: The mean ages of the patients were 8.4 ± 2.5 and 9 ± 4.3 years in the control and intervention groups, respectively. Male participants constituted 36 (50.7%) and 35 (49.3%) in the control and intervention groups, respectively. In both the treatment and control groups, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) significantly decreased over six months during the study (P < 0.001). AST level (IU/L) was significantly lower in the children who received vitamin E than controls at one-month (P = 0.01), two-month (P = 0.002), three-month (P = 0.005), four-month (P < 0.001), and six-month (P = 0.002) post-treatment periods. There was no significant difference comparing ALT between the intervention and control groups except for two months post-treatment (P = 0.01). Conclusions: Our study showed that the administration of vitamin E in children with acute hepatitis A can accelerate liver enzyme normalization. | en |
| DOI | https://doi.org/10.5812/archcid.100591 | en |
| URI | https://brieflands.com/journals/archcid/articles/100591 | en |
| Keyword | Hepatitis A Virus | en |
| Keyword | Aspartate Aminotransferases | en |
| Keyword | Vitamin E | en |
| Publisher | Brieflands | en |
| Title | Accelerating Effects of Vitamin E Supplementation on Liver Enzyme Normalization in Children with Acute Hepatitis A Infection; a Single-Blinded Clinical Trial | en |
| Type | Research Article | en |
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