The Effects of Flecainide on QT Interval and Dispersion in Brugada Syndrome: Insights from a Retrospective Analysis
| Author | Seyed Shahin Eftekhari | en |
| Author | Seyyed Mojtaba Hashemizadeh | en |
| Author | Hossein Nokhbe Zaeim | en |
| Author | Lotfolah Feizi Barnaji | en |
| Issued Date | 2025-06-30 | en |
| Abstract | Background: Brugada syndrome (BrS) is a genetic cardiac disorder characterized by specific electrocardiogram (ECG) abnormalities and a heightened risk of sudden cardiac death. The role of antiarrhythmic drugs, particularly flecainide, in modifying ECG parameters in BrS patients’ remains underexplored. Objectives: This study aims to evaluate the effects of flecainide on the QT interval and QT dispersion in patients diagnosed with or suspected of having BrS. Methods: A retrospective analysis was conducted involving 20 patients, divided into two groups: Ten diagnosed with BrS and 10 without. Each participant received a 300 mg oral dose of flecainide, followed by continuous ECG monitoring for 24 hours. Key ECG parameters, including the QT interval, QTc interval, and QT dispersion, were analyzed pre-and-post-administration. Results: Post-flecainide administration, a significant increase in the right QT interval was observed in the overall cohort (P = 0.04). Notably, while BrS patients exhibited changes, none were statistically significant. In contrast, non-BrS patients showed significant increases in left QTD, right QT, and right QTc intervals (P = 0.02, P = 0.03, P = 0.02, respectively). Conclusions: Flecainide significantly alters ECG parameters, particularly in non-Brugada patients, emphasizing its diagnostic utility in confirming BrS. These findings highlight the need for refined diagnostic strategies and tailored management approaches for patients at risk of arrhythmogenic events. | en |
| DOI | https://doi.org/10.5812/intjcardiovascpract-160642 | en |
| URI | https://brieflands.com/journals/ijcp/articles/160642 | en |
| Keyword | Brugada Syndrome | en |
| Keyword | Flecainide | en |
| Keyword | QT Interval | en |
| Keyword | Electrocardiogram | en |
| Keyword | Sudden Cardiac Death | en |
| Publisher | Brieflands | en |
| Title | The Effects of Flecainide on QT Interval and Dispersion in Brugada Syndrome: Insights from a Retrospective Analysis | en |
| Type | Research Article | en |
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