Melanoma and Associated MicroRNAs
| Author | Negin Afrang | en |
| Author | Mehrnaz Imani | en |
| Author | Maryam Honardoost | en |
| Issued Date | 2016-12-23 | en |
| Abstract | Context: Melanoma is an invasive type of skin cancer, with a rapidly increasing incidence. Therefore, new approaches are required to treat this aggressive cancer. MicroRNAs (miRNAs) are introduced as novel components in melanoma. This review study aimed to determine the relationship between melanoma and miRNAs. Evidence Acquisition: Prognostic, diagnostic, and therapeutic applications of miRNAs in skin cancer have been recently investigated from different aspects. Some of these studies on miRNAs were reviewed, and the mechanisms of some genetic modifications were determined in this study. Results: Since recommendations for miRNAs have increased in the past decades, and scientists have confirmed their great efficacy in multiple aspects of cancer treatment, different strategies have been developed considering their therapeutic effects. Therefore, further studies are required to confirm miRNA application in melanoma treatment. Conclusions: This review study included various investigations concerning miRNA traces as molecular rearrangements in melanoma. It was revealed that multiple miRNAs are efficient in molecular signaling and can be used as prognostic, diagnostic, and therapeutic biomarkers. Although the exact relationship between aberrant expression of miRNAs and cancers has been confirmed, further studies are required to introduce more thorough and accurate applications of miRNAs in melanoma. | en |
| DOI | https://doi.org/10.5812/jssc.63854 | en |
| URI | https://brieflands.com/journals/jssc/articles/63854 | en |
| Keyword | Melanoma | en |
| Keyword | MicroRNAs | en |
| Keyword | Cancer | en |
| Publisher | Brieflands | en |
| Title | Melanoma and Associated MicroRNAs | en |
| Type | Review Article | en |
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