Simple Synthesis and Biological Evaluation of Some Benzimidazoles Using Sodium Hexafluroaluminate, Na3AlF6, as an Efficient Catalyst

Author	Akbar Mobinikhaledi	en
Author	Ahmad Hamta	en
Author	Mehdi Kalhor	en
Author	Mehdi Shariatzadeh	en
Issued Date	2014-01-31	en
Abstract	Considerable attention has been focused on the synthesis of benzimidazoles due to having a broad spectrum of biological activities such as anti-parasitic, fungicidal, anti-thelemintic and anti-inflammatory activities. As a part of our research work in this area, a series of benzimidasole derivatives (3a-n) were synthesized in good to high yields by reaction of o-phenylenediamine and different aromatic aldehydes in the presence of sodium hexafluroaluminate, Na3AlF6, as an efficient catalyst at 50 ◦C. This environmentally benign and practical method offers several advantages, such as high yields, use of available catalyst, mild reaction conditions and easy workup. The antibacterial activity of these benzimidasoles was also evaluated using Staphylococcus aureus (mm) and Escherichia coli (mm) bacterial strain. All synthesized materials were characterized using IR and NMR spectroscopy as well as microanalyses data.	en
DOI	https://doi.org/10.22037/ijpr.2014.1386	en
Keyword	Aromatic aldehydes	en
Keyword	Bbenzimidaazole	en
Keyword	Catalyst	en
Keyword	<i>o-</i>Phenylenediamine	en
Publisher	Brieflands	en
Title	<b>Simple Synthesis and Biological Evaluation of Some Benzimidazoles Using Sodium Hexafluroaluminate, Na</b><sub><b>3</b></sub><b>AlF</b><sub><b>6</b></sub><b>, as an Efficient Catalyst</b>	en
Type	Original Article	en

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