Association of Interleukin 13/+110 Gene Polymorphism with Hepatitis B Virus Infection in Golestan Province, Northern Iran
| Author | Maryam Zangi | en |
| Author | Azam Bakhshandeh | en |
| Author | Masoumeh Mehrpouya | en |
| Author | Majid Shahbazi | en |
| Orcid | Majid Shahbazi [0000-0002-4143-8282] | en |
| Issued Date | 2019-03-31 | en |
| Abstract | Background: The most common primary cause of liver cancer is hepatocellular carcinoma (HCC). Cytokines as mediators have significant roles in immune and inflammatory responses. Interleukin-13 (IL-13) is a potent pleiotropic cytokine. Objectives: The aim of this study was to evaluate the association of IL-13/+110 gene polymorphism in patients with chronic hepatitis B virus (HBV), one of the most important factors that lead to the development of HCC. Methods: DNA was extracted from peripheral blood cells of all 585 participants including 302 unrelated Hepatitis B surface antigen (HBS-Ag) positives and 283 healthy matched groups. The IL-13 gene polymorphism (+ 110 A or G) was genotyped by SSP-PCR method and then genotype frequencies were checked by using the Pearson’s chi-square test and/or Fisher exact test. Results: The frequencies of A/G genotype (CI = 1.18 - 2.34, OR = 1.66, P = 0.004) and A/A genotype (CI = 0.95 - 3.53, OR = 1.84, P = 0.071) were higher in the patients. Also, the frequency of A allele was remarkably higher in the HBV patients than control group (CI = 1.09 - 1.79, OR = 1.84, P = 0.071). Conclusions: High frequency of A allele in patients rather than control group suggested that A allele probably plays a role in augmenting susceptibility to HBV infection risk and high frequency of G allele in controls suggested this allele has a protective role in this disease. | en |
| DOI | https://doi.org/10.5812/jjm.68270 | en |
| Keyword | Hepatitis B Virus (HBV) | en |
| Keyword | Hepatocellular Carcinoma (HCC) | en |
| Keyword | Interleukin-13 | en |
| Keyword | Polymerase Chain Reaction (PCR) | en |
| Keyword | Polymorphism | en |
| Publisher | Brieflands | en |
| Title | Association of Interleukin 13/+110 Gene Polymorphism with Hepatitis B Virus Infection in Golestan Province, Northern Iran | en |
| Type | Research Article | en |
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