Lovastatin Incubation Improves Acetylcholine-Induced Relaxation in Isolated Aortic Rings of Diabetic Rat
| Author | Heydar Parsaee | en |
| Author | Mohsen Imenshahidi | en |
| Author | Zahra Fatehi | en |
| Issued Date | 2006-07-31 | en |
| Abstract | To evaluate the acute effect of lovastatin on diabetic endothelial dysfunction, we examined this effect on the aortic rings of streptozotocin-diabetic rats. The endothelial function was assessed in aortic rings isolated from diabetic rats, 12 weeks after treatment with streptozotocin (45 mg/kg, i.p.). The concentration-response curve to acetylcholine (Ach) in the aortic rings precontracted with phenylephrine (10-6 M) was significantly diminished in diabetic groups; and maximum relaxation in control and diabetic groups were 82±1.93% and 48±2.39% respectively (a 42% decrease, P | en |
| DOI | https://doi.org/10.22037/ijpr.2010.674 | en |
| Keyword | Endothelium | en |
| Keyword | Streptozotocin | en |
| Keyword | Diabetes | en |
| Keyword | Rat aortic rings | en |
| Keyword | Lovastatin | en |
| Keyword | Antioxidant | en |
| Publisher | Brieflands | en |
| Title | Lovastatin Incubation Improves Acetylcholine-Induced Relaxation in Isolated Aortic Rings of Diabetic Rat | en |
| Type | Research Article | en |