Type of Immunodeficiency, Treatment and Outcomes of Serious BCG Vaccine Complications: A 15 Year Survey
| Author | Samileh Noorbakhsh | en |
| Author | Ahmad Siadati | en |
| Author | Setareh Mamishi | en |
| Author | Lida Fereidoni | en |
| Author | Jalil Kooh Paiezadeh | en |
| Issued Date | 2007-12-31 | en |
| Abstract | Background:To describe the immunologic characteristics and outcomes of the patients with serious BCG complication in a 15- year survey.Materials and Methods: A descriptive and retrospective study was performed in 2 referral pediatric infectious wards of central Children Hospital, and Rasool Akram Hospital Tehran, Iran between 1989 and 2004.Results: We studied 76 patients (72% male and 28% female) with serious BCG complications. mean age of 14.41± 1.43 months the results were follows:severe combined immunodeficiency 15.7 % of cases Leukopenia 1.4%; lymphopenia in 2.8%; cell mediated immunodeficiency in 26.3 %, chronic granulomatous disease in 11.2%, common variable immunodeficiency 6.5 %; NK cell deficiency in 5.2%; isolated CD4 deficiency in 5.1 %; hyper IgM syndrome in 1.4 %, mild abnormality in nitroblue tetrazolium (NBT) test 4.2 %;mild hypogammaglobulinemia in 4.2 % and idiopathic disseminated BCG infection in 15.7% of patients.Nineteen patients died due to progressive disseminated mycobacterial infections.Conclusion: N.k cell deficiency has yet reported as a risk factor for progression and complication of BCG infection. we suggest combination therapy with IFN-? and chemotherapy in all cases of" idiopathic disseminated BCG infections. | en |
| DOI | https://doi.org/ | en |
| Keyword | BCG compliacation | en |
| Keyword | Gamma Interferon | en |
| Keyword | BCG vaccine | en |
| Keyword | Immunodeficiency | en |
| Publisher | Brieflands | en |
| Title | Type of Immunodeficiency, Treatment and Outcomes of Serious BCG Vaccine Complications: A 15 Year Survey | en |
| Type | Research Article | en |
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