Enhancement Evaluation of Energy Deposition and Secondary Particle Production in Gold Nanoparticle Aided Tumor Using Proton Therapy
| Author | Somaye Malmir | en |
| Author | Ali Asghar Mowlavi | en |
| Author | Saeed Mohammadi | en |
| Issued Date | 2017-10-31 | en |
| Abstract | Background: Numerous qualitative studies have been carried out on the safety and clinical use of GNPs as a radio-sensitizer in tumors, using proton therapy and the results have been promising. However, some quantitative studies should be conducted in order to examine the factors affecting this method. Methods: Monte Carlo simulation was performed by MCNPX code to assess pristine Bragg peak, spread-out bragg peak (SOBP), and secondary particle production enhancement in GNPs radio-sensitized tumor using proton therapy. Results: The results show several percent dose enhancement within and its reduction after the tumor site. A little increase in neutron production and no deviation for photon production is indicated. Conclusions: Finally, it can be concluded that sensitization of a realistic tumor can be beneficial during the proton therapy. | en |
| DOI | https://doi.org/10.5812/ijcm.10719 | en |
| Keyword | Proton Therapy | en |
| Keyword | GNPs Radio-Sensitization | en |
| Keyword | Modulated Dose Enhancement | en |
| Keyword | Secondary Particles | en |
| Keyword | Slab Head Phantom | en |
| Publisher | Brieflands | en |
| Title | Enhancement Evaluation of Energy Deposition and Secondary Particle Production in Gold Nanoparticle Aided Tumor Using Proton Therapy | en |
| Type | Research Article | en |
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