Paraquat Exposure Up-regulates Cyclooxygenase-2 in the Lungs, Liver and Kidneys in Rats
| Author | Hassan Malekinejad | en |
| Author | Aysa Rezabakhsh | en |
| Author | Fatemeh Rahmani | en |
| Author | Mazdak Razi | en |
| Issued Date | 2013-10-31 | en |
| Abstract | Paraquat is a commonly used herbicide in many countries which can lead to systematic poisoning on exposure, In this study, paraquat (PQ)-induced changes in the expression of Cyclooxygenase-2 (COX-2) along with biochemical and histopathological changes in the lungs, liver and kidneys were studied. Twenty four male Wistar rats (180-200 g) were exposed either against saline as control group or various doses of PQ (3.5, 7 and 10 mg/kg, SC) as test groups for 7 consecutive days. The animals in test groups demonstrated a significant increase of malondialdehyde and NO contents, while a remarkable decrease of total thiol molecules was recorded. Histopathological studies revealed a severe alveolar edema and hemorrhages in the lungs, congestion and glycogen degeneration in the liver and multifocal interstitial nephritis along with proximal tubular degeneration in the kidneys. PQ up-regulated the COX-2 expression at mRNA level significantly in the examined organs. This data suggest that the PQ-induced oxidative disturbances and pathological damages can be attributed to the upregulation of COX-2 in examined organs. | en |
| DOI | https://doi.org/10.22037/ijpr.2013.1358 | en |
| Keyword | Alveolar Edema | en |
| Keyword | Cyclooxigenase-2 | en |
| Keyword | Liver | en |
| Keyword | Multifocal Interstitial Nephritis | en |
| Keyword | Paraquat | en |
| Publisher | Brieflands | en |
| Title | Paraquat Exposure Up-regulates Cyclooxygenase-2 in the Lungs, Liver and Kidneys in Rats | en |
| Type | Original Article | en |
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