Umbelliprenin from <i>Ferula szowitsiana</i> Activates both Intrinsic and Extrinsic Pathways of Apoptosis in Jurkat T-CLL cell line
| Author | Omid Gholami | en |
| Author | Mahmood Jeddi-Tehrani | en |
| Author | Mehrdad Iranshahi | en |
| Author | Amir Hassan Zarnani | en |
| Author | Seyed Ali Ziai | en |
| Issued Date | 2013-07-31 | en |
| Abstract | Umbelliprenin is a prenylated compound, which belongs to the class of sesquiterpene coumarins. It is extracted from dried roots of Ferula szwitsiana collected from the mountains of Golestan forest (Golestan Province, north of Iran). Induction of apoptosis in Jurkat T-CLL cells has been previously shown. In this study, effect of umbelliprenin on proapoptotic caspases (caspase-8 and -9) and antiapoptotic Bcl-2 family protein was studied. Jurkat cells were incubated with umbelliprenin. Cells were then lysed and activation of proteins was studied by Western blot analysis. | en |
| DOI | https://doi.org/10.22037/ijpr.2013.1341 | en |
| Keyword | Umbellprenin | en |
| Keyword | CLL | en |
| Keyword | Apoptosis | en |
| Keyword | Caspase | en |
| Keyword | Western blot | en |
| Publisher | Brieflands | en |
| Title | Umbelliprenin from <i>Ferula szowitsiana</i> Activates both Intrinsic and Extrinsic Pathways of Apoptosis in Jurkat T-CLL cell line | en |
| Type | Original Article | en |
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