Clinical Characteristics and Outcomes of COVID-19 in Pediatric Cancer Patients: A Retrospective Cohort Study

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AuthorSara Badiepouren
AuthorSharareh Kamfaren
AuthorSamin Alavien
AuthorShahnaz Arminen
AuthorReza Taherianen
OrcidSamin Alavi [0000-0001-8118-7329]en
OrcidShahnaz Armin [0000-0002-4993-482X]en
OrcidReza Taherian [0000-0002-9658-130X]en
Issued Date2025-04-30en
AbstractBackground: The impact of COVID-19 on pediatric cancer patients remains a critical area of investigation. Objectives: This study aimed to compare the clinical characteristics and outcomes of COVID-19 in children with and without malignancies. Methods: A retrospective cohort study was conducted at Mofid Children's Hospital in Tehran, Iran, from July 2020 to December 2022. The study included 210 children with confirmed SARS-CoV-2 infection: 105 with malignancies (case group) and 105 without malignancies (control group). Clinical presentations, laboratory parameters, imaging findings, and outcomes were analyzed. Results: Conclusions: Pediatric cancer patients with COVID-19 exhibited more severe symptoms and distinct laboratory and imaging findings compared to non-cancer patients. While mortality rates were similar, the trend toward higher risk in the malignancy group highlights the need for specialized management strategies for this vulnerable population.en
DOIhttps://doi.org/10.5812/apid-153545en
KeywordCOVID-19en
KeywordPediatricsen
KeywordMalignancyen
KeywordClinical Manifestationsen
KeywordLaboratory Findingsen
KeywordImaging Findingsen
PublisherBrieflandsen
TitleClinical Characteristics and Outcomes of COVID-19 in Pediatric Cancer Patients: A Retrospective Cohort Studyen
TypeResearch Articleen

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