PAG Masked Protective Physical Exercise-Induced High H<sub>2</sub>S Levels in 5/6 Nephrectomized Rats
| Author | Behjat Seifi | en |
| Author | Mehri Kadkhodaei | en |
| Author | Enayatollah Bakhshi | en |
| Author | Abdollah Sajedizadeh | en |
| Author | Mina Ranjbaran | en |
| Author | Mahdi Hajiaqaei | en |
| Orcid | Behjat Seifi [0000-0002-2082-968X] | en |
| Orcid | Mehri Kadkhodaei [0000-0003-0458-6662] | en |
| Orcid | Enayatollah Bakhshi [0000-0001-8049-0190] | en |
| Orcid | Mina Ranjbaran [0000-0003-4791-8911] | en |
| Orcid | Mahdi Hajiaqaei [0000-0001-6166-3340] | en |
| Issued Date | 2024-12-31 | en |
| Abstract | Background: To investigate the mechanisms of exercise therapeutics in preclinical animal models of chronic kidney disease (CKD), PAG (D, L-propargylglycine), an inhibitor of hydrogen sulfide production, was used to examine the protective effects of physical activity on oxidative stress and inflammation levels during CKD. Methods: Male Wistar rats with CKD, induced by the 5/6 nephrectomy procedure and subjected to 8 weeks of exercise training, received injections of PAG, a cystathionine γ-lyase (CSE) inhibitor, at a dose of 19 mg/kg, i.p., twice a week during those 8 weeks. The systolic blood pressure (BP) and renal sympathetic nerve activity (RSNA) were assessed. Additionally, plasma creatinine, BUN, renal hydrogen sulfide (H2S) levels, oxidative stress, and inflammatory markers were evaluated. Results: In the PAG group, inhibition of H2S production significantly reversed the improvements in plasma creatinine, BUN, renal malondialdehyde (MDA) level, superoxide dismutase (SOD) activity, TNF-α, and IL-6 that were achieved by exercise. Additionally, high RSNA and high BP, which were also reversed in the PAG group, compared to the CKD group subjected to exercise training. Conclusions: The results suggest that the improvement in BP, oxidative stress, and inflammation status by exercise in CKD may be at least partially due to CSE/H2S signaling. | en |
| DOI | https://doi.org/10.5812/ijpr-145620 | en |
| Keyword | 5/6 Nephrectomy | en |
| Keyword | Exercise | en |
| Keyword | Hydrogen Sulfide | en |
| Keyword | PAG | en |
| Keyword | Hypertension | en |
| Keyword | RSNA | en |
| Publisher | Brieflands | en |
| Title | PAG Masked Protective Physical Exercise-Induced High H<sub>2</sub>S Levels in 5/6 Nephrectomized Rats | en |
| Type | Research Article | en |
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