Chemometrics-Assisted Spectrophotometric Method Development and Validation for Simultaneous Estimation of Emtricitabine, Tenofovir Alafenamide Fumarate, and Dolutegravir Sodium in Dosage Form

Abstract

Aim: This study aims on the development of a chemometric-assisted spectroscopic method for the analysisof combined dosage form of emtricitabine (EMT), tenofovir alafenamide fumarate (TEN), and dolutegravirsodium (DOL). The use of a multivariate algorithm to analyse spectrophotometric data is a novel approachto estimating drug concentrations in formulations.