Hepatitis B Immune Globulin in Liver Transplantation Prophylaxis: An Update
| Author | Payam Dindoost | en |
| Author | Seyed Mohammad Jazayeri | en |
| Author | Seyed Moayed Alavian | en |
| Orcid | Seyed Moayed Alavian [0000-0002-4443-6602] | en |
| Issued Date | 2012-03-31 | en |
| Abstract | Context: Liver transplantation is the best treatment option for end-stage liver disease following hepatitis B (HBV) infection. However, the high rate of recurrence of HBV infection following transplantation is a disadvantage of this option.Evidence Acquisition: Over the past 2 decades, the gold standard of prophylactic treatment for the prevention of HBV re-infection following liver transplantation has been the administration of low- to high-dose hepatitis B immune globulin (HBIg) along with an antiviral agent to induce passive immunity.Results: The effectiveness of HBIg in preventing the recurrence of HBV depends on the dosage, route of administration, and duration of HBIg treatment, and the viremic status at the time of transplantation. There is currently no consensus on a standardized recommendation for therapeutic options that include HBIg administration.Conclusion: This review attempts to summarize the available data on the feasibility of such options. Most recent studies support the use of long-term combination therapy of HBIg and antiviral NAs (especially new agents). Implication for health policy/practice/research/medical education:The article is suitable for hepatologist, internists, infectious specialists and liver transplantation departments. Please cite this paper as:Dindoost P, Jazayeri SM, Alavian SM. Hepatitis B Immune Globulin and Liver Transplantation Prophylaxis: An UpDate. Hepat Mon.2012;12(3):168-76. DOI: 10.5812/hepatmon.832 Copyright © 2012 Kowsar Corp. All rights reserved. | en |
| DOI | https://doi.org/10.5812/hepatmon.832 | en |
| Keyword | Liver Transplantation | en |
| Keyword | Hepatitis B Hyperimmune Globulin | en |
| Keyword | Prevention and Control | en |
| Publisher | Brieflands | en |
| Title | Hepatitis B Immune Globulin in Liver Transplantation Prophylaxis: An Update | en |
| Type | Review Article | en |
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