Determination of Mirtazapine and Desmethyl Mirtazapine in Human Plasma by a New Validated HPLC Ultraviolet Method with a Simple and Reliable Extraction Method: Application to Therapeutic Drug Monitoring Study by 62 Real Patient Plasma
| Author | Emrah Dural | en |
| Author | Nilay Sedes Baskak | en |
| Author | Hatice Özcan | en |
| Author | Yağmur Kır | en |
| Author | Bora Başkak | en |
| Author | Halil Sinan Süzen | en |
| Issued Date | 2020-01-31 | en |
| Abstract | Determination of mirtazapine (MRP) during psychopharmacotherapy in biological fluids is essential to achieve successful therapy, to avoid toxicity related to drug interactions, genetic variability, and poor compliance. A new, rapid, and sensitive high-performance liquid chromatography method has been developed in human plasma for the determination of MRP and N-desmethylmirtazapine (NDM) that is an active metabolite. | en |
| DOI | https://doi.org/10.22037/ijpr.2019.14599.12519 | en |
| Keyword | Mirtazapine | en |
| Keyword | N-desmethylmirtazapine | en |
| Keyword | Plasma | en |
| Keyword | HPLC-UV | en |
| Keyword | Therapeutic drug monitoring | en |
| Keyword | Validation | en |
| Publisher | Brieflands | en |
| Title | Determination of Mirtazapine and Desmethyl Mirtazapine in Human Plasma by a New Validated HPLC Ultraviolet Method with a Simple and Reliable Extraction Method: Application to Therapeutic Drug Monitoring Study by 62 Real Patient Plasma | en |
| Type | Original Article | en |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- ijpr-19-18.pdf
- Size:
- 467.62 KB
- Format:
- Adobe Portable Document Format
- Description:
- Article/s PDF