Therapeutic Effect of Ferulago angulata Extract on Reproductive Parameters and serum testosterone levels in Diabetic Male Rats

Abstract

Diabetes is an important metabolic disease inducing different effects on body organs, especially reproductive system. Increased oxidative stress and antioxidant capacity changed in diabetes induce infertility and decrease the sperm parameters. This study was to evaluate the therapeutic effects of hydro alcoholic extract of Ferulago angulata on reproductive parameters in diabetic male rats. In this experimental study, we used 30 male Wistar rats (230- 250g) with an average age of 10 weeks. A total of 24 rats were made diabetes type I by 40 mg/kg streptozotosin. Animals were divided into 5 groups of control, diabetic, and diabetic+ Ferulago angulata extract (100, 200 and 400mg/kg). Sperm parameters, serum testosterone level, seminiferous tubules diameter, and germ line epithelium maturity were assayed at the end of study. Data were analyzed by one‐way ANOVA test and P