Efficient Synthesis and Antimicrobial Evaluation of Pyrazolopyranopyrimidines in the Presence of SBA-Pr-SO3H as a Nanoporous Acid Catalyst
| Author | Ghodsi Mohammadi Ziarani | en |
| Author | Faezeh Aleali | en |
| Author | Negar Lashgari | en |
| Author | Alireza Badiei | en |
| Author | Ali Abolhasani Soorki | en |
| Issued Date | 2018-04-30 | en |
| Abstract | A simple, efficient, and environmentally friendly method has been developed for the synthesis of a series of tricyclic fused pyrazolopyranopyrimidines via a one-pot three-component reaction of barbituric acids, aromatic aldehydes, and 3-methyl-5-pyrazolone in the presence of SBA-Pr-SO3H. SBA-15 mesoporous silica material functionalized with propyl sulfonic acid groups was used as a heterogeneous Brønsted acid catalyst with hexagonal structure, high surface area, thick walls, and large uniform pores. All reactions were performed under reflux conditions in water in the presence of a catalytic amount of SBA-Pr-SO3H. High yields, mild reaction conditions, short reaction times, and simple work-up procedures are some advantages of this method. The antimicrobial activities of the synthesized compounds were also evaluated and some products exhibited significant antibacterial activities at low concentrations. | en |
| DOI | https://doi.org/10.22037/ijpr.2018.2204 | en |
| Keyword | SBA-Pr-SO<sub>3</sub>H | en |
| Keyword | Green synthesis | en |
| Keyword | Antimicrobial activity | en |
| Keyword | Barbituric acid | en |
| Keyword | Pyranopyrimidine | en |
| Publisher | Brieflands | en |
| Title | Efficient Synthesis and Antimicrobial Evaluation of Pyrazolopyranopyrimidines in the Presence of SBA-Pr-SO3H as a Nanoporous Acid Catalyst | en |
| Type | Original Article | en |
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