Synthesis and Study of Some New Quinolone Derivatives Containing a 3-acetyl Coumarin for Their Antibacterial and Antifungal Activities
| Author | Edris Valadbeigi | en |
| Author | Shahram Ghodsi | en |
| Issued Date | 2017-04-30 | en |
| Abstract | A series of N-[2-(8-metoxy-2H-chromen-2-one)ethyl] piperazinyl quinolones containing a carbonyl related functional groups (oxo or oxyimino) on the ethyl spacer of coumarin and piperazin rings was synthesized and studied for their antibacterial and antifungal activities . The synthesis of compounds (6a-6l) was achieved through the versatile and efficient synthetic route that involved reaction of quinolones with appropriately α- bromo ketone or α- bromo oxime derivatives (2, 2a-c). The structures of the new compounds were confirmed by IR, Mass, 1H-NMR and 13C-NMR spectra. More good activities against gram-positive and gram-negative are shown in all compounds. The antifungal data reveals that all compounds have shown weak antifungal activity as compared to Nistatin. | en |
| DOI | https://doi.org/10.22037/ijpr.2017.2028 | en |
| URI | https://brieflands.com/journals/ijpr/articles/125005 | en |
| Keyword | Antimicrobial | en |
| Keyword | Chemical synthesis | en |
| Keyword | Coumarin | en |
| Keyword | Piperazin derivative | en |
| Keyword | Quinolones | en |
| Publisher | Brieflands | en |
| Title | Synthesis and Study of Some New Quinolone Derivatives Containing a 3-acetyl Coumarin for Their Antibacterial and Antifungal Activities | en |
| Type | Original Article | en |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- ijpr-16-554.pdf
- Size:
- 536.61 KB
- Format:
- Adobe Portable Document Format
- Description:
- Article/s PDF