A Study on Genetic Association of Interleukin-16 Single Nucleotide Polymorphism (rs1131445) With Chronic Hepatitis B Virus Infection in Iranian Patients
| Author | Abbas Behelgardi | en |
| Author | Seyed Masoud Hosseini | en |
| Author | Seyed Reza Mohebbi | en |
| Author | Pedram Azimzadeh | en |
| Author | Shaghayegh Derakhshani | en |
| Author | Khatoon Karimi | en |
| Author | Afsaneh Sharifian | en |
| Author | Mohammad Reza Zali | en |
| Issued Date | 2015-11-01 | en |
| Abstract | Background: Interleukin-16 (IL-16) is an immunomodulatory cytokine, which plays an important role in some inflammatory and autoimmune diseases such as hepatitis B, which is a major health concern worldwide. Objectives: In this study, we aimed to investigate the plausible association between IL-16 polymorphism and chronic HBV susceptibility in an Iranian population. Patients and Methods: In a case-control study, we analyzed rs1131445 polymorphism in the microRNA binding site of the IL-16 gene in 262 patients with chronic hepatitis B and 269 healthy controls, using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method and DNA sequencing technology to confirm our results. Results: Altogether, in this investigation, a significant association was observed between the IL-16 TC genotype compared with the TT genotype (OR = 0.696, 95% CI: 0.485 - 0.997, P = 0.048), after adjustments for confounders including age and gender. Conclusions: These findings show that immunogenetic factors, such as single nucleotide polymorphism in IL-16, could be a risk factor for susceptibility to chronic HBV infection. However, further investigations are needed to verify these results. | en |
| DOI | https://doi.org/10.5812/jjm.23411 | en |
| Keyword | Hepatitis B Virus | en |
| Keyword | Cytokines | en |
| Keyword | Polymorphism | en |
| Keyword | Single Nucleotide | en |
| Keyword | Polymerase Chain Reaction | en |
| Keyword | Restriction Fragment Length | en |
| Keyword | Iran | en |
| Publisher | Brieflands | en |
| Title | A Study on Genetic Association of Interleukin-16 Single Nucleotide Polymorphism (rs1131445) With Chronic Hepatitis B Virus Infection in Iranian Patients | en |
| Type | Research Article | en |
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