Synthesis and Characterization of Hydrazide-Hydrazone Derivatives of 3-Pyridine Carboxylic Acid as Antimycobacterial Tuberculosis Agents

Abstract

In this study synthesis of nicotinoyl hydrazone derivatives is investigated by introducing the nicotinicacidhydrazidepharmacophore into several molecules and screening for antimycobacterial activity. Benzaldehyde derivatives react with nicotinicacidhydrazideto form nicotinoylhydrazones.The synthesized compounds were screened against M. tuberculosis H37Rv, clinical isolates of M. tuberculosis and MDR clinical isolates of M. tuberculosisusing the proportion test. The minimum inhibitory concentration (MIC) of N'-(4-methylphenyl) nicotinicacidhydrazone and N'-(4-(N,N-dimethyl)phenyl)nicotinicacidhydrazone exhibited activity between 40 and 200μg/mL and could be a good start point to find new lead compounds against M. tuberculosis.