Evaluation of Clinicopathologic Characteristics and Survival Rates of Patients with Renal Cell Carcinoma in Northeast of Iran

Abstract

Background: Renal cell carcinoma (RCC) is the 9th most common cancer in men and the 14th most common in women. To date, there remains considerable uncertainty regarding factors that influence the survival of RCC patients. Objectives: This study aimed to determine the clinicopathologic characteristics and outcomes of RCC over a 15-year period in northeast Iran. Methods: Data were collected from RCC patient records at Omid and Imam Reza Hospitals and Reza Radiation Oncology Center from 2001 to 2016. Demographic and clinicopathological data were extracted from patient records, and the current status of participants was assessed through telephone follow-ups. Overall and disease-free survival were analyzed using SPSS version 20. Results: A total of 230 RCC patients were enrolled in this study. The majority of patients were male, with a mean age of 56.78 years. Overweight status was common among patients, and pain was the most frequently reported symptom. The most common histologic subtype was clear cell carcinoma. The median follow-up period was 10.50 months, with overall survival rates at 1, 3, 5, and 10 years being 74.8%, 52.2%, 44.8%, and 39.6%, respectively. The mean overall and disease-free survival rates were approximately 24 and 25 months, respectively. Survival was significantly associated with RCC histologic subtype, disease stage, hemoglobin level, and underweight status. In contrast, sex, type of surgery, and chemotherapy regimen did not significantly impact survival. Conclusions: Renal cell carcinoma patient survival was influenced by histologic subtype, disease stage, low hemoglobin levels, and underweight status.