Antispasmodic Activity of Onion (Allium cepa L.) Peel Extract on Rat Ileum

Abstract

Onion (Allium cepa) bulb from Liliaceae has antioxidant, spasmolytic and antihypertensive activities. The aim of present study was to investigate the antispasmodic effect of onion peel on rat ileum contractility. Onion peel powder was extracted by maceration in 70% alcohol for 72 h. A terminal portion of ileum from male Wistar rat was dissected and its contractions were recorded isotonically in an organ bath containing Tyrode solution (37°C) under 1 g tension. Extract cumulative concentrations (0.1, 0.2 and 0.4 mg/ml) reduced the ileum contractions induced by KCl (60 mM) and carbachol (10 µM) dose-dependently (P