Prevalence of Hepatitis G Virus and Co-Infection with Hepatitis B Virus and Hepatitis C Virus Among Hemodialysis Patients in Ahvaz, Iran
| Author | Alireza Sanchooli | en |
| Author | Manoochehr Makvandi | en |
| Author | Niloofar Nisi | en |
| Author | Rahil Nahid Samiei | en |
| Orcid | Manoochehr Makvandi [0000-0003-2510-3033] | en |
| Issued Date | 2018-04-30 | en |
| Abstract | Background: Patients on hemodialysis are at a high-risk for acquiring blood-borne infections, such as hepatitis G, hepatitis C, and hepatitis B viruses. The aim of this investigation was to determine the prevalence of HGV infection among patients on hemodialysis and its co-infection with hepatitis C and B viruses in Ahvaz. Methods: Blood samples were collected from patients on hemodialysis during January to July, 2016. RNAs were extracted from sera and cDNA was prepared using the kit. The nested-polymerase chain reaction (PCR) and sequencing of positive samples were carried out to determine hepatitis G virus genotypes. In addition, to evaluate the co-infection of HGV with hepatitis C and hepatitis B virus infections, the sera of all the individuals were tested for hepatitis C virus antibody and HBs-Ag by enzyme linked immunosorbent assay (ELISA) assay. Results: The HGV RNA was found in 10% of the patients with dominant genotype 2a. About 2% of the patients on hemodialysis were co-infected with hepatitis C virus while 1% of them was co-infected with hepatitis B virus. The statistical analysis revealed that there was a significant correlation (P < 0.01) between duration of the hemodialysis process and hepatitis G virus infectivity. Conclusions: The present study showed that patients, who used the hemodialysis devices in this city, were infected with Hepatitis G, hepatitis B, and hepatitis C viruses. The data indicates that duration of dialysis is significantly related to infection of Hepatitis G virus. Therefore, it is critical to control the sterility of these equipment for intercepting cross-infectivity. | en |
| DOI | https://doi.org/10.5812/jjcdc.66417 | en |
| Keyword | GB Virus C | en |
| Keyword | Prevalence | en |
| Keyword | Hepatitis B Virus | en |
| Keyword | Hepatitis C Virus | en |
| Publisher | Brieflands | en |
| Title | Prevalence of Hepatitis G Virus and Co-Infection with Hepatitis B Virus and Hepatitis C Virus Among Hemodialysis Patients in Ahvaz, Iran | en |
| Type | Research Article | en |
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