Effect of Berberis vulgaris fruit extract on alpha-fetoprotein gene expression and chemical carcinogen metabolizing enzymes activities in hepatocarcinogenesis rats

Abstract

Objective: Cancer is the second cause of death worldwide, among them liver cancer is the fifth most important malignancy. The aim of this study was to investigate chemopreventive activity of Berberis vulgaris fruit extract in hepatocarcinogenesis Sprague dawley rats.