Effect of Tadalafil on Heart Function in Children with Severe Pulmonary Regurgitation Following Surgical Repair of Tetralogy of Fallot: A Prospective Study
| Author | Mohammadreza Edraki | en |
| Author | Poria Moradi | en |
| Author | Nima Mehdizadegan | en |
| Author | Navid Omidifar | en |
| Author | Hamid Amoozgar | en |
| Author | Hamid Mohammadi | en |
| Author | Amir Naghshzan | en |
| Author | Kambiz Keshavarz | en |
| Orcid | Mohammadreza Edraki [0000-0003-2026-2764] | en |
| Orcid | Nima Mehdizadegan [0000-0001-6538-1391] | en |
| Orcid | Navid Omidifar [0000-0003-3391-926X] | en |
| Orcid | Hamid Mohammadi [0000-0002-6606-2795] | en |
| Orcid | Amir Naghshzan [0000-0001-7647-178X] | en |
| Orcid | Kambiz Keshavarz [0000-0002-9728-4112] | en |
| Issued Date | 2024-12-31 | en |
| Abstract | Background: Tetralogy of Fallot (TOF) is the most prevalent cyanotic congenital heart defect. Pulmonary regurgitation (PR) is a common sequela following most surgical repairs for TOF. Tadalafil might reduce pulmonary vascular resistance after Tetralogy of Fallot total correction (TOFTC). Objectives: This study evaluated the efficacy of tadalafil in reducing PR volume and improving heart function among TOFTC children with severe PR, using transthoracic echocardiography, particularly focusing on changes in N-terminal pro-b-type natriuretic peptide (NT-proBNP). Methods: The present study was conducted on TOFTC patients consecutively between September 2019 and August 2020 at Shiraz University of Medical Sciences, Shiraz, Iran. M-mode and two-dimensional (2D) Doppler echocardiography were performed, and NT-proBNP levels were measured in 20 patients before and one month after tadalafil administration. SPSS version 23.0 was utilized to analyze all results. Results: The patients' ages ranged from 25 to 128 months. The mean age and weight of the patients were 67.9 ± 34.5 months and 21.1 ± 6.9 kg, respectively. Tadalafil administration did not significantly improve Doppler and tissue Doppler parameters; however, it increased the pulmonary valve pressure gradient and velocity-time integral. Additionally, tadalafil had no significant effect on improving NT-proBNP levels. The Spearman correlation test did not show any significant correlation between the pulmonary valve pressure gradient and velocity-time integral with age, weight, and NT-proBNP. Conclusions: Tadalafil increased the pulmonary valve pressure gradient and velocity-time integral in TOFTC patients with severe PR; however, it did not affect NT-proBNP levels or tissue Doppler parameters. | en |
| DOI | https://doi.org/10.5812/ijp-146372 | en |
| Keyword | Congenital Heart Disease | en |
| Keyword | Tetralogy of Fallot | en |
| Keyword | NT-proBNP | en |
| Keyword | Transthoracic Echocardiography | en |
| Publisher | Brieflands | en |
| Title | Effect of Tadalafil on Heart Function in Children with Severe Pulmonary Regurgitation Following Surgical Repair of Tetralogy of Fallot: A Prospective Study | en |
| Type | Research Article | en |
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