Synthesis and Antibacterial Evaluation of (S,Z)-4-methyl-2-(4-oxo-5-((5-substituted phenylfuran-2-yl) methylene)-2-thioxothiazolidin-3-yl)Pentanoic Acids
| Author | Ming-Xia Song | en |
| Author | Xian-Qing Deng | en |
| Author | Zhi-Yu Wei | en |
| Author | Chang-Ji Zheng | en |
| Author | Yan Wu | en |
| Author | Chang-Shan An | en |
| Author | Hu-Ri Piao | en |
| Issued Date | 2015-01-31 | en |
| Abstract | The microbial resistance has become a global hazard with the irrational use of antibiotics. Infection of drug-resistant bacteria seriously threatens human health. Currently, there is an urgent need for the development of novel antimicrobial agents with new mechanisms and lower levels of toxicity. In this paper, a series of (S,Z)-4-methyl-2-(4-oxo-5-((5-substitutedphenylfuran-2-yl) methylene)-2-thioxothiazolidin-3-yl)pentanoic acids via a Knoevenagel condensation were synthesized and evaluated for their antibacterial activity in-vitro. The synthesized compounds were characterized by IR, 1H NMR and MS. The antibacterial test in-vitro showed that all of the synthesized compounds had good antibacterial activity against several Gram-positive bacteria (including multidrug-resistant clinical isolates) with minimum inhibitory concentration (MIC) values in the range of 2–4 µg/mL. Especially compounds 4c, 4d, 4e and 4f were the most potent, with MIC values of 2 µg/mL against four multidrug-resistant Gram-positive bacterial strains. | en |
| DOI | https://doi.org/10.22037/ijpr.2015.1622 | en |
| URI | https://brieflands.com/journals/ijpr/articles/125265 | en |
| Keyword | Furan | en |
| Keyword | Pentanoic acid | en |
| Keyword | Antibacterial activity | en |
| Keyword | Cytotoxicity | en |
| Keyword | MRSA | en |
| Keyword | QRSA | en |
| Publisher | Brieflands | en |
| Title | Synthesis and Antibacterial Evaluation of (S,Z)-4-methyl-2-(4-oxo-5-((5-substituted phenylfuran-2-yl) methylene)-2-thioxothiazolidin-3-yl)Pentanoic Acids | en |
| Type | Original Article | en |
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