Association between <i>Mycoplasma pneumoniae </i>Infection and Coronary Artery Aneurysm in Children with Kawasaki Disease
| Author | Cheng-Yi Wang | en |
| Author | Chao-Min Song | en |
| Author | Guang-Hua Liu | en |
| Author | Huijie Zhang | en |
| Author | Fang-Sheng Chen | en |
| Author | Han Lin | en |
| Orcid | Cheng-Yi Wang [0000-0002-1258-1020] | en |
| Orcid | Guang-Hua Liu [0000-0001-9692-5857] | en |
| Issued Date | 2020-12-02 | en |
| Abstract | Background: The epidemiology of Kawasaki disease (KD) suggests that an infectious agent may be a potential disease trigger in susceptible children. Several studies have shown that the cause of KD may be associated with Mycoplasma pneumoniae (M. pneumoniae) infection. Objectives: We aimed to investigate the relationship between M. pneumoniae infection and coronary artery aneurysm (CAA) in children with KD in China. Methods: From January 2015 to December 2018, a total of 330 children with KD met the inclusion criteria. Relevant data were extracted and analysed. Results: The children were stratified into two groups according to M. pneumoniae infection status. Significant differences were identified in the proportion of patients with fever > 10 days, the occurrence of small CAA, and the average serum sodium, pre-albumin (PA), and albumin levels but not in the occurrence of medium and giant CAA between the two groups. According to binary logistic regression, M. pneumoniae infection (OR: 0.515; 95% CI: 0.309 - 0.860; P = 0.011), serum sodium levels (OR: 0.910; 95% CI: 0.851 - 0.972; P =0.005), and PA (OR: 0.900; 95% CI: 0.854 - 0.949; P ≤ 0.001) levels were independently associated with occurrence of small CAA. Conclusions: We demonstrated that M. pneumoniae infection, serum sodium and PA levels are inversely related to the occurrence of small CAA. These results suggest that M. pneumoniae infection may be associated with a decreased incidence of small CAA. Further large-sample studies are needed. | en |
| DOI | https://doi.org/10.5812/ijp.104737 | en |
| Keyword | <i>Mycoplasma pneumoniae</i> | en |
| Keyword | Coronary Artery Aneurysm | en |
| Keyword | Kawasaki Disease | en |
| Keyword | China | en |
| Publisher | Brieflands | en |
| Title | Association between <i>Mycoplasma pneumoniae </i>Infection and Coronary Artery Aneurysm in Children with Kawasaki Disease | en |
| Type | Research Article | en |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- ijp-31-1-104737.pdf
- Size:
- 185.95 KB
- Format:
- Adobe Portable Document Format
- Description:
- Article/s PDF