Green Nanotechnology-based Gold Nanomaterials for Hepatic Cancer Therapeutics: A Systematic Review
| Author | Hamed Barabadi | en |
| Author | Thomas J. Webster | en |
| Author | Hossein Vahidi | en |
| Author | Hamed Sabori | en |
| Author | Kaveh Damavandi Kamali | en |
| Author | Fereshteh Jazayeri Shoushtari | en |
| Author | Mohammad Ali Mahjoub | en |
| Author | Masoumeh Rashedi | en |
| Author | Ebrahim Mostafavi | en |
| Author | David Medina Cruz | en |
| Author | Omid Hosseini | en |
| Author | Muthupandian Saravana | en |
| Issued Date | 2020-07-31 | en |
| Abstract | The objective of the current study was to systematically review the in-vitro anticancer activity of green synthesized gold nanoparticles (AuNPs) against hepatic cancer cells. The articles were identified through electronic databases, including PubMed, Scopus, Embase, Web of Science, Science Direct, ProQuest, and Cochrane. In total, 20 articles were found eligible to enter into our systematic review. Our findings showed that 65% of the articles used herbal extracts for the synthesis of AuNPs. Significantly, almost all of the articles stated the biofabrication of AuNPs below 100 nm in diameter. Impressively, most of the studies showed significant anticancer activity against HepG2 cells. Molecular studies stated the induction of apoptosis through the AuNPs-treated cells. We provided valuable information about the molecular mechanisms of AuNPs-induced cytotoxicity against HepG2 cells as well as their biocompatibility. The studies represented that AuNPs can be effective as anticancer drug nanocarrier for drug delivery systems. In addition, AuNP surface functionalization provides an opportunity to design multifunctional nanoparticles by conjugating them to diagnostic and/or therapeutic agents for theranostic purposes. Overall, our findings depicted considerable biogenic AuNPs-induced cytotoxicity, however, future studies should assess the anticancer activity of biogenic AuNPs through in-vivo studies, which was missing from such studies. | en |
| DOI | https://doi.org/10.22037/ijpr.2020.113820.14504 | en |
| Keyword | Nanotoxicity | en |
| Keyword | Hepatic cancer | en |
| Keyword | Gold nanoparticles | en |
| Keyword | Biosynthesis | en |
| Keyword | Anticancer activity | en |
| Publisher | Brieflands | en |
| Title | Green Nanotechnology-based Gold Nanomaterials for Hepatic Cancer Therapeutics: A Systematic Review | en |
| Type | Review Article_imported | en |
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