Synthesis and Antimycobacterial Activity of 2-(Phenylthio) benzoylarylhydrazone Derivatives
| Author | Ali Almasirad | en |
| Author | Somayeh Samiee-Sadr | en |
| Author | Abbas Shafiee | en |
| Issued Date | 2011-10-31 | en |
| Abstract | A series of new 2-(phenylthio) benzoylarylhydrazones were synthesized by acid-catalyzed condensation of hydrazide 3 with corresponding aldehydes. The chemical structures of the compounds were elucidated by FT-IR, 1H-NMR and Mass spectra. All newly synthesized compounds were evaluated for their antimycobacterial activities against Mycobacterium tuberculosis H37Rv using the microplatealamar blue assay (MABA). Compounds 4f (5-Nitro-2-furyl analogue) and 4g (5-Nitro-2-thienyl analogue) showed antimycobacterial activity with IC90, 7.57 and 2.96 μg/mL, respectively. | en |
| DOI | https://doi.org/10.22037/ijpr.2011.984 | en |
| Keyword | Hydrazones | en |
| Keyword | Antimycobacterial activity | en |
| Keyword | Mycobacterium tuberculosis | en |
| Keyword | 5-Nitrofuran | en |
| Keyword | 5-Nitrothiophen | en |
| Publisher | Brieflands | en |
| Title | Synthesis and Antimycobacterial Activity of 2-(Phenylthio) benzoylarylhydrazone Derivatives | en |
| Type | Original Article | en |
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