Expression of T-cell Immunoglobulin- and Mucin-domain-containing Molecule-3 on Lymphocytes from Henoch-Schoenlein Purpura Patients
| Author | Yuan Li-ping | en |
| Author | Yan Bo | en |
| Author | Lu Ling | en |
| Author | Hu Bo | en |
| Issued Date | 2013-06-30 | en |
| Abstract | Objective: To investigate T-cell immunoglobulin domain and mucin domain-containing molecule-3 (Tim-3) and its ligand galectin-9 mRNA expression in peripheral blood mononuclear cells (PBMCs) from Henoch-Schoenlein Purpura (HSP) patients. Methods: Quantitative real-time reverse transcription-polymerase chain reaction (PCR) was used to examine the mRNA expression of Tim-3 and its ligand galectin-9 in PBMCs from HSP patients. ELISA methods were used to examine the levels of serum IFN-γ and immunoglobulin A1 (IgA1). The Spearman rank test was used for correlation analysis between Tim-3, galectin-9 mRNA expression and serum IFN-γ and IgA1 levels, respectively. Findings: The results showed that Tim-3 and galectin-9 mRNA expression was obviously higher in patients, which was closely correlated with serum IFN-γ and IgA1, respectively. Conclusion: The results suggested that Tim-3/Tim-3L may be related to the pathogenesis of HSP. | en |
| DOI | https://doi.org/ | en |
| Keyword | Henoch-Schoenlein Purpura | en |
| Keyword | T-cell Immunoglobulin | en |
| Keyword | Mucin domain containing 3 protein | en |
| Keyword | TIM-3 protein | en |
| Keyword | Immunoglobulin A | en |
| Publisher | Brieflands | en |
| Title | Expression of T-cell Immunoglobulin- and Mucin-domain-containing Molecule-3 on Lymphocytes from Henoch-Schoenlein Purpura Patients | en |
| Type | Brief Report | en |
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