The Effect of <i>Otostegia</i><i>persica</i> in Combination with Chloroquine on Chloroquine-Sensitive and Chloroquine-Resistant Strains of <i>Plasmodium berghei</i> Using <i>In-vivo</i> Fixed Ratios Method

Abstract

Malaria is one of the worldwide parasitic diseases which threaten the life of hundreds of millions of people at the malarious areas each year. The emergence of chloroquine-resistant strains of Plasmodium falciparum in most of the malarious areas has encountered the relevant countries with some difficulties about treating the acute cases of the disease particulary if the monotherapy regimen has been used. Because of many advantages for the combination therapy, the effectiveness of chloroquine (CQ) and Otostegia persica (OP), a medicinal plant in combination form, was tested against the chloroquine-sensitive and chloroquine-resistant strains of Plasmodium berghei in sourian mouse using in-vivo adapted fixed ratios method in this study.