Oral Diazepam for Preventing Febrile Seizures After Vaccination: A Randomized Controlled Trial
| Author | Shahram Nasiri | en |
| Author | Gholamreza Jelodar | en |
| Author | Meisam Babaei | en |
| Author | Ali Akbar Momen | en |
| Author | Shahram Sadeghvand | en |
| Author | Saeed Hesam | en |
| Author | Maryam Kordnezhadian | en |
| Issued Date | 2026-08-31 | en |
| Abstract | Background: Febrile seizures are a common reason for pediatric emergency visits and may also occur after vaccination. Objectives: This study aimed to evaluate the effect of prophylactic oral diazepam on recurrence of febrile seizures after vaccination. Methods: This randomized clinical trial was conducted in 2023 among 128 children with a history of post-vaccination febrile seizures. Participants were randomly assigned to two equal groups. The intervention group received oral diazepam (1 mg/kg/day; maximum dose, 5 mg every 8 hours) for 48 hours after vaccination, whereas the control group received rectal diazepam only as rescue therapy. Outcomes were assessed on days 3, 7, and 14 after vaccination. Results: On day 7 after vaccination, febrile seizures occurred in 0% of the oral diazepam group and 9.37% of the control group, indicating a significant difference (P = 0.012). On day 14, febrile seizures were observed in 3.12% of the intervention group versus 12.5% of the control group (P = 0.048). Overall, seizure recurrence remained consistently lower in the diazepam group across follow-up visits. Regarding safety, adverse effects were reported in 18.75% of the intervention group and 9.37% of the control group, with no statistically significant difference (P = 0.12). Conclusions: Prophylactic oral diazepam may reduce the recurrence of post-vaccination febrile seizures in children. Larger studies are needed to confirm these findings. | en |
| DOI | https://doi.org/10.5812/jcp-168497 | en |
| URI | https://brieflands.com/journals/jcp/articles/168497 | en |
| Keyword | Febrile Seizures | en |
| Keyword | Diazepam | en |
| Keyword | Vaccination | en |
| Keyword | Pediatrics | en |
| Publisher | Brieflands | en |
| Title | Oral Diazepam for Preventing Febrile Seizures After Vaccination: A Randomized Controlled Trial | en |
| Type | Research Article | en |
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