A Comparative Study of Risperidone and Aripiprazole in Attention Deficit Hyperactivity Disorder in Children Under Six Years Old: A Randomized Double-Blind Study
| Author | Katayoon Razjouyan | en |
| Author | Arash Danesh | en |
| Author | Mojgan Khademi | en |
| Author | Rozita Davari-Ashtiani | en |
| Author | Simasadat Noorbakhsh | en |
| Orcid | Mojgan Khademi [0000-0001-7051-1605] | en |
| Issued Date | 2018-02-28 | en |
| Abstract | Background: Stimulants are not very effective on attention deficit hyperactivity disorder (ADHD) children under 6 years old. The most common medication that is used in this range of age is Risperidone. Evaluating the safety and efficacy of Aripiprazole versus Risperidone for treating children under 6 years suffering from ADHD was the aim of this study. Methods: During this double-blind clinical trial, 34 children aged 3 - 6 years who were diagnosed with ADHD, received treatments with Aripiprazole or Risperidone randomly for 12 weeks. Follow-up measures comprised, CGAS, the ADHD-RS, CPRS and side effect checklist. Results: The findings revealed that 20 patients in Risperidone group (including 13 boys and 7 girls) and 20 patients in Aripiprazole group (including 13 boys and 7 girls) had at least one follow-up examination. After 12 weeks of the study, both medications showed distinct improvements in ADHD RS (P < 0.001), CPRS (P < 0.001) and CGAS (P < 0.001) scores. The statistic difference between them was not significantly different. The most common side effects in Risperidone group were reported to be panic (20%), nausea and vomiting (20%), while in Aripiprazole they were reported to be increased appetite (25%) and somnolence (15%). Conclusions: The findings revealed that both Risperidone and Aripiprazole are effective in treating ADHD children under 6 years old and there was no significant difference between the two drugs. Children can tolerate them well. Aripiprazole effect on children showed itself earlier compared to Risperidone. | en |
| DOI | https://doi.org/10.5812/ijp.60087 | en |
| Keyword | Attention Deficit Disorder with Hyperactivity | en |
| Keyword | Risperidone | en |
| Keyword | Aripiprazole | en |
| Keyword | Antipsychotic Agents | en |
| Keyword | Attention | en |
| Keyword | Clinical Trial | en |
| Keyword | Children | en |
| Publisher | Brieflands | en |
| Title | A Comparative Study of Risperidone and Aripiprazole in Attention Deficit Hyperactivity Disorder in Children Under Six Years Old: A Randomized Double-Blind Study | en |
| Type | Research Article | en |
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