Non-Invasive Histologic Markers of Liver Disease in Patients With Chronic Hepatitis B
| Author | Simin Dokht Shoaei | en |
| Author | Shahnaz Sali | en |
| Author | Mehdi Karamipour | en |
| Author | Esmail Riahi | en |
| Issued Date | 2014-02-01 | en |
| Abstract | Background: An exact histologic staging of liver fibrosis is essential for identifying the best therapeutic strategy and determining the disease prognosis in patients with chronic hepatitis B (CHB). While liver biopsy has a vital role in the management of liver diseases, it also sustains some limitations hampering its widespread use. Objectives: In this study, we evaluated and compared several available indices of the severity of liver diseases in patients with hepatitis. Patients and Methods: Exclusion criteria were as follows: decompensated liver disease, alcoholic liver disease or alcohol intake of 40 g or more per week; co-infection with human immunodeficiency virus, hepatitis C virus, or hepatitis D virus. Results: Results showed that AST to platelet ratio index (APRI) (odds ratio = 2.35, P = 0.01) and age (odds ratio = 1.04, P = 0.007) were independently predictive of the presence of significant liver necrosis and inflammation. On the other hand, AARPRI (odds ratio = 3.8, P = 0.07), age (odds ratio = 1.04, P = 0.02), and ALT levels (odds ratio = 1.01, P = 0.007) were predictive of a significant liver fibrosis. Further analysis with receiver-operating curve showed that none of these predictors had a fair diagnostic value (area under the curve < 70). Conclusions: The APRI had the highest sensitivity and specificity (64% and 71%, respectively) for prediction of the presence of liver disease. We suggest that APRI may be applicable for the detection of a severe liver disease. | en |
| DOI | https://doi.org/10.5812/hepatmon.14228 | en |
| Keyword | Chronic Hepatitis B | en |
| Keyword | Liver Cirrhosis | en |
| Keyword | Liver Disease | en |
| Publisher | Brieflands | en |
| Title | Non-Invasive Histologic Markers of Liver Disease in Patients With Chronic Hepatitis B | en |
| Type | Research Article | en |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- 15342-pdf.pdf
- Size:
- 108.23 KB
- Format:
- Adobe Portable Document Format
- Description:
- Article/s PDF