Analysis of the Clinical Efficacy of Infliximab in the Treatment of Steroid-Refractory Ulcerative Colitis in Children
| Author | Ying Chen | en |
| Author | Feiwen Xiao | en |
| Author | Yang Wang | en |
| Author | Mei Sun | en |
| Author | Xu Teng | en |
| Orcid | Xu Teng [0000-0002-0566-5859] | en |
| Issued Date | 2022-06-30 | en |
| Abstract | Background: Incidence of ulcerative colitis (UC) in children has increased worldwide. Objectives: In the current study, we summarized our clinical experience using infliximab (IFX) in the treatment of children with steroid-refractory UC. Methods: The clinical data of 9 steroid-refractory UC patients with average age of 8 years who were treated with IFX in our hospital were analyzed. Results: At the end of the induction period, 6 achieved a clinically significant response. Of the 6 children, 4 had mucosal healing and 2 had endoscopic remission. At week 30, among the 6 children who achieved a clinically significant response, 3 had persistent clinical remission and mucosal healing, 1 achieved mucosal healing from endoscopic remission, 1 had mild disease, and the other child had not reached 30 weeks of treatment as of this writing. At week 54, 6 of 9 children achieved clinical remission and 5 had mucosal healing. The hemoglobin concentration in the children who achieved a clinically significant response was higher than pre-treatment and the inflammation markers were lower than pre-treatment. During IFX treatment, five children had a loss of response, three had a primary non-response, and two had a secondary non-response. The latter children achieved clinical remission with optimized treatment. Conclusions: IFX is a salvage treatment option for children with moderate-to-severe steroid-refractory UC. The course of treatment and the timing of drug withdrawal warrants further study. | en |
| DOI | https://doi.org/10.5812/ijp-119605 | en |
| Keyword | Infliximab | en |
| Keyword | Steroid-Refractory | en |
| Keyword | Ulcerative Colitis | en |
| Keyword | Children | en |
| Publisher | Brieflands | en |
| Title | Analysis of the Clinical Efficacy of Infliximab in the Treatment of Steroid-Refractory Ulcerative Colitis in Children | en |
| Type | Research Article | en |
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