Investigating the Prevalence and Determinants of Vitamin D Deficiency in Children with Epilepsy Treated with Anticonvulsant Drugs: An Analytical Cross-Sectional Study
| Author | Azita Tavasoli | en |
| Author | Mitra Sadrian | en |
| Author | Maryam Kachuei | en |
| Author | Mohammad Rezazadeh | en |
| Orcid | Mohammad Rezazadeh [0009-0004-6570-927X] | en |
| Accessioned Date | 2025-07-09T01:32:01Z | |
| Issued Date | 2025-08-31 | en |
| Abstract | Background: The potential risk factors for vitamin D deficiency in children with epilepsy, particularly those receiving antiseizure medications (ASMs), remain unclear. Objectives: This study aimed to evaluate the determinants of 25-hydroxyvitamin D insufficiency in pediatric epileptic patients treated with ASMs. Methods: This cross-sectional analytical study assessed the prevalence and predictive factors of vitamin D deficiency in 45 children aged 1 to 14 years with epilepsy who were treated with ASMs between 2020 and 2021. Serum vitamin D levels were measured using the chemiluminescence method. Levels below 30 ng/mL were defined as insufficient. Results: Forty-five epileptic children with a mean age of 6.31 ± 3.97 years were included in the study. The mean serum vitamin D level was 24.18 ng/mL, and 26 (57.7%) were identified as having vitamin D insufficiency. Children with insufficient levels were significantly older (P = 0.002) and had received ASMs for a longer duration (P = 0.034). Age was the only significant determinant of vitamin D insufficiency. Receiver operating characteristic (ROC) analysis showed that age effectively predicted vitamin D deficiency with an area under the curve (AUC) of 0.754. Conclusions: This study highlights a high prevalence of vitamin D insufficiency among epileptic children treated with ASMs, particularly in older age groups. Regular monitoring of serum vitamin D levels, early diagnosis, timely treatment, and prophylactic supplementation are recommended to prevent complications. | en |
| DOI | https://doi.org/10.5812/jcp-163192 | en |
| URI | https://repository.brieflands.com/handle/123456789/65352 | |
| Keyword | Pediatrics | en |
| Keyword | Epilepsy | en |
| Keyword | Vitamin D Deficiency | en |
| Keyword | Anti-Seizure Medication | en |
| Keyword | Vitamin D | en |
| Publisher | Brieflands | en |
| Title | Investigating the Prevalence and Determinants of Vitamin D Deficiency in Children with Epilepsy Treated with Anticonvulsant Drugs: An Analytical Cross-Sectional Study | en |
| Type | Research Article | en |
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