Serum Aminotransferases in Thai Children With Dengue Infection
| Author | Olarn Prommalikit | en |
| Author | Usa Thisyakorn | en |
| Author | Chule Thisyakorn | en |
| Issued Date | 2015-12-28 | en |
| Abstract | Background:: Hepatic manifestations are one of the unusual manifestations of dengue infection. Objectives:: We conducted this study in order to study the pattern of serum aminotransferases and sequential changes before and after shock in Thai children with dengue infection. Patients and Methods:: Children who were clinically and serologically diagnosed as dengue infection and were admitted to King Chulalongkorn Memorial Hospital during a peroid of one year were enrolled. They were clinically classified into a non-shock group and a shock group. The majority of serum aminotransferases including aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were obtained within a week after the onset of fever and until 3 days after shock in the shock group. Student t-test and median in boxplot form were used for statistical analysis. Results:: We enrolled 127 children with a mean age of 7.6 ± 3.6 years. The incidence of abnormal AST and ALT levels was 97.4% and 50.0% in the shock group, and 91.8% and 44.9% in the non-shock group respectively. 29% and 15.4% of the patients in shock group and only 10.2% and 4.1% in non-shock group had the respective AST and ALT levels > 200 U/L. Serum aminotransferase levels were significantly higher in the shock group when compared to the non-shock group. AST tended to increase starting from one day before shock and continued to increase within a few days whereas ALT was less likely to be affected. Conclusions:: Elevated serum aminotransferases are a common finding in children with dengue infection and the levels of AST are higher than those of ALT. Patients with shock have significantly higher aminotransferase levels that increase up to 3 days after shock. | en |
| DOI | https://doi.org/10.5812/ijp.443 | en |
| Keyword | Dengue | en |
| Keyword | Serum Aminotransferases | en |
| Keyword | Infection | en |
| Publisher | Brieflands | en |
| Title | Serum Aminotransferases in Thai Children With Dengue Infection | en |
| Type | Research Article | en |
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