Updates on Advanced Therapies for Acute Pulmonary Embolism

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Venous thromboembolism is the third common vascular disease after acute myocardial infarction and stroke, and acute pulmonary embolism (PE) remains as the most common preventable cause of in-hospital mortality. In addition to routine anticoagulant therapy, several advanced treatment options have been introduced over the past three decades. We provide a succinct and contemporary summary of the evidence base and important indications for inferior vena caval filter placement, systemic and catheter-based thrombolytic therapy, as well as percutaneous and surgical thrombectomy. Appropriate case selection for advance therapies for PE could minimize the adverse effects and costs, while optimizing the outcomes.

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