Th<sub>1</sub>/Th<sub>2</sub> Cytokine Profile and Its Diagnostic Value in <i>Mycoplasma pneumoniae</i> Pneumonia
| Author | Wei Li | en |
| Author | Yu-jie Liu | en |
| Author | Xiao-le Zhao | en |
| Author | Shi-qiang Shang | en |
| Author | Lang Wu | en |
| Author | Qing Ye | en |
| Author | Hui Xu | en |
| Issued Date | 2016-02-28 | en |
| Abstract | Background:: The levels of Th1/Th2 cytokine can alter in pathogenic infection in children with pneumonia. Objectives:: To evaluate Th1/Th2 cytokine profile and its diagnostic value in M. pneumoniae pneumonia in children. Patients and Methods:: Children with M. pneumoniae mono-infection and 30 healthy children were tested with cytokines assay. We used real time PCR to detect M. pneumoniae in children with pneumonia. Results:: M. pneumoniae test was positive in 2188 (16.62%) out of 13161 pneumonia children. Children aged 5 - 9 years had the highest rate and summer was a season with high rate of M. pneumoniae incidence in Zhejiang province. During the course of study, in 526 pneumonia children with M. pneumoniae mono-infection and 30 healthy children cytokines assay was performed. IL-2 level of M. pneumoniae pneumonia children was lower than that of healthy children (median levels, pg/mL: IL-2: 3.2 vs. 5.7, P = 0.00), while IL-4, IL-10 and IFN-γ were higher than in healthy children (median levels, pg/mL: IL-4: 3.2 vs. 1.5, P = 0.00; IL-10: 5.6 vs. 2.5, P = 0.001; IFN-γ: 20.4 vs. 4.8, P = 0.001). Conclusions:: IL-2 decreases and IL-4, IL-10 and IFN-γ increase in children with M. pneumoniae pneumonia, which has a promising prospect in diagnosis of this disease in clinical practice. | en |
| DOI | https://doi.org/10.5812/ijp.3807 | en |
| URI | https://brieflands.com/journals/ijp/articles/3807 | en |
| Keyword | Cytokines | en |
| Keyword | Pneumonia | en |
| Keyword | Children | en |
| Keyword | <i>M. pneumoniae</i> | en |
| Publisher | Brieflands | en |
| Title | Th<sub>1</sub>/Th<sub>2</sub> Cytokine Profile and Its Diagnostic Value in <i>Mycoplasma pneumoniae</i> Pneumonia | en |
| Type | Research Article | en |
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