Evaluation of Involvement of Axillary Lymph Nodes with Ki-67 Expression in Patients with Breast Cancer
| Author | Mahdi Asadi | en |
| Author | Aghigh Ziaeemehr | en |
| Author | Soodabeh Shahidsales | en |
| Author | Seyed Amir Aledavood | en |
| Author | Kazem Anvari | en |
| Author | Marjan Mirsadraee | en |
| Author | Maryam Nemati | en |
| Author | Amir Avan | en |
| Author | Elaheh Aghel | en |
| Orcid | Aghigh Ziaeemehr [0000-0001-6821-2358] | en |
| Orcid | Soodabeh Shahidsales [0000-0003-2782-351X] | en |
| Orcid | Kazem Anvari [0000-0002-1080-1907] | en |
| Issued Date | 2018-08-31 | en |
| Abstract | Background: Breast cancer is the first leading cause of cancer-related deaths in women. Ki-67 is being used for evaluation of the prognosis of patients with breast cancer. Objectives: The aim of the current study was to explore the association of the involvement of axillary lymph nodes status with the expression of Ki-67 in patients with breast cancer. Methods: A total of 449 patients were enrolled followed by evaluation of the association of Ki67 levels with demographic, pathologic, and survival data of patients, using Chi-square, logistic regression models, student t test and Mann-Whitney. Results: We observed a significant relationship between the expression level of Ki-67 and stage of tumor (P = 0.012), positive progesterone receptor (P = 0.003), and subtype pathologic features (P < 0.05). Also, a significant difference was detected between Her2 and expression level of Ki-67 (P = 0.015). Survival analysis showed the association for Ki-67 (P = 0.02), age (P = 0.005), stage of tumor (P < 0.05), lymph node involvement (P = 0.001), and the Her2 (P = 0.024) with clinical outcome (e.g., overall survival or disease free survival) of patients with breast cancer. Conclusions: The results of this study demonstrated that the overexpression of Ki-67 was associated with large tumors, progesterone receptor expression, and stage of tumor, but it was not related with lymph node involvement. | en |
| DOI | https://doi.org/10.5812/ijcm.66567 | en |
| Keyword | Breast Cancer | en |
| Keyword | Ki-67 | en |
| Keyword | Lymph Node Involvement | en |
| Publisher | Brieflands | en |
| Title | Evaluation of Involvement of Axillary Lymph Nodes with Ki-67 Expression in Patients with Breast Cancer | en |
| Type | Research Article | en |
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