Efficacy of Inhaled Colistin in Critically Ill Children with Ventilator-Associated Pneumonia Resistant to Multiple Drugs
| Author | Ghamartaj Khanbabaee | en |
| Author | Maryam Mir Jafari | en |
| Author | Azita Behzad | en |
| Author | Seyedeh Masumeh Hashemi | en |
| Author | Seyedeh Narjes Ahmadizadeh | en |
| Author | Maryam Alemzadeh | en |
| Author | Bahador Mirrahimi | en |
| Orcid | Maryam Mir Jafari [0009-0009-8492-4182] | en |
| Orcid | Azita Behzad [0000-0001-5399-6735] | en |
| Orcid | Seyedeh Masumeh Hashemi [0000-0003-4253-5188] | en |
| Orcid | Seyedeh Narjes Ahmadizadeh [0000-0003-2690-6487] | en |
| Orcid | Bahador Mirrahimi [0000-0001-7276-8770] | en |
| Issued Date | 2024-11-30 | en |
| Abstract | Background: Ventilator-associated pneumonia (VAP) is the leading cause of death related to mechanical ventilation and the most common nosocomial infection in the intensive care unit (ICU). Objectives: This study aimed to investigate the efficacy of adjunctive inhaled colistin in critically ill children with multidrug-resistant ventilator-associated pneumonia (MDR-VAP). Methods: In this prospective cohort study, 80 critically ill patients aged 2 to 18 years with MDR-VAP were admitted to the PICU of Mofid Children's Hospital in Tehran between 2019 and the end of 2022. Eligible patients were divided into two equal groups: The colistin group (receiving inhaled colistin in addition to other antibiotics) and the control group (receiving only intravenous antibiotics). Clinical and laboratory findings were compared between the two groups. Results: The mean ages of participants in the control and colistin groups were 21.2 ± 2.9 and 24.9 ± 1.7 months, respectively (P = 0.51). The duration of hospital stay in the colistin group was 34.92 ± 20.03 days, compared to 29.83 ± 22.35 days in the control group, which was not statistically significant (P = 0.29). The duration of mechanical ventilation use was similar between the control group (23.15 ± 21.17 days) and the colistin group (24.06 ± 17.87 days) (P = 0.83). Mortality rates were also comparable, with 65% in the control group and 57.5% in the colistin group (P = 0.49). Conclusions: Inhaled colistin did not significantly reduce the duration of hospitalization, the duration of mechanical ventilation use, or the mortality rate in critically ill children with MDR-VAP. Further multicenter studies with larger sample sizes are recommended to validate these findings. | en |
| DOI | https://doi.org/10.5812/jcp-151869 | en |
| URI | https://brieflands.com/journals/jcp/articles/151869 | en |
| Keyword | Colistin | en |
| Keyword | Gram Negative Bacteria | en |
| Keyword | Ventilator-Associated Pneumonia | en |
| Keyword | Pediatrics | en |
| Publisher | Brieflands | en |
| Title | Efficacy of Inhaled Colistin in Critically Ill Children with Ventilator-Associated Pneumonia Resistant to Multiple Drugs | en |
| Type | Research Article | en |
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