Evaluation of the Celecoxib Effect against Radiotherapy Induced Acute Toxicities in the Patients with Prostate Cancer Compared with Placebo Group
| Author | Saeedeh Mir Mohammadi Rad | en |
| Author | Mohsen Bakhshandeh | en |
| Author | Mahmoud Reza Aghamiri | en |
| Author | Marzieh Rohani-Rassf | en |
| Author | Mona Malekzadeh Moghani | en |
| Author | Alireza Khoshghadam | en |
| Author | Ehsan Akbari Hamed | en |
| Orcid | Mohsen Bakhshandeh [0000-0002-6546-7483] | en |
| Issued Date | 2017-12-31 | en |
| Abstract | Background: Acute toxicities in patients with prostate cancer who accede to radiation therapy usually affect the patients’ quality of life and these toxicities are sometimes dose limiting. Objectives: This study was performed to determine the efficacy and safety of celecoxib together with radiation therapy. Methods: Forty prostate cancer patients undergoing external beam radiotherapy (EBRT) were enrolled to receive either placebo or celecoxib. The patients received external-beam radiotherapy up to 70 Gy daily fractions of 1.8 - 2 Gy. The patients received oral celecoxib or placebo 200 mg twice daily. The first celecoxib or placebo was administered 3 hours before each radiotherapy fraction and the second, 12 hours after the first consumption. RTOG based gastrointestinal (GI) and genitourinary (GU) acute toxicity scoring were performed pre-treatment, at least once weekly during radiotherapy and once 1 month after the end of the treatment. Results: Celecoxib was well tolerated. Thirty-nine patients (39/40) fully completed treatment according to protocol. No grade 4 toxicity was seen in two groups. A significant reduction in GU ≥ 2 toxicity was observed in the celecoxib group (P = 0. 006). No significant difference was found between the two groups with respect to GI ≥ 2 toxicity (P = 0. 621). Conclusions: We demonstrated that the combination of celecoxib with radiotherapy is well tolerated and decreased acute toxicities especially GU toxicity in patients with prostate cancer. | en |
| DOI | https://doi.org/10.5812/ijcm.9484 | en |
| Keyword | Celecoxib | en |
| Keyword | Acute Toxicity | en |
| Keyword | Prostate Cancer | en |
| Keyword | Radiotherapy | en |
| Publisher | Brieflands | en |
| Title | Evaluation of the Celecoxib Effect against Radiotherapy Induced Acute Toxicities in the Patients with Prostate Cancer Compared with Placebo Group | en |
| Type | Research Article | en |
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