Evaluation and Comparison of Urinary Cytokines for the Diagnosis of Acute Pyelonephritis
| Author | Azar Nickavar | en |
| Author | Baranak Safaeian | en |
| Author | Ehsan Valavi | en |
| Issued Date | 2016-10-01 | en |
| Abstract | Background: The accurate diagnosis and management of febrile urinary tract infection (UTI) is a clinical challenge in the absence of specific clinical and laboratory findings in infants and young children. Objectives: The aim of this study was to identify and compare the diagnostic and therapeutic implications of recently introduced cytokines for the diagnosis of acute pyelonephritis (APN). Methods: This multicenter prospective study was performed on 37 (female/male = 6.5:1) children with symptomatic culture-proven APN and 37 (female/male = 1.6/1) age-matched febrile children without UTIs as the control group. Urine samples were obtained before antibiotic treatment in both groups and 3 - 4 days after treatment in the UTI group, and evaluated for interleukin (IL)-1α, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, tumor necrosis factor-α (TNFα), monocyte chemoattractant protein-1 (MCP-1), and vascular endothelial growth factor (VEGF) using an ELISA immunoassay kit. Results: Mean urinary IL-1α, IL-4, IL-6, and IL-8 concentrations significantly increased in the acute phase of APN compared to the control group, and decreased following antibiotic treatment. Conclusions: We recommend routine urinalysis and urine culture for the diagnosis of children with APN. Urinary IL-4 was a relatively good cytokine for the prediction and treatment-monitoring of children with acute febrile UTI. | en |
| DOI | https://doi.org/10.5812/pedinfect.38877 | en |
| URI | https://brieflands.com/journals/apid/articles/20324 | en |
| Keyword | Pyelonephritis | en |
| Keyword | Cytokine | en |
| Keyword | Urinary Cytokine | en |
| Keyword | Interleukin | en |
| Keyword | Urinary Tract Infection | en |
| Publisher | Brieflands | en |
| Title | Evaluation and Comparison of Urinary Cytokines for the Diagnosis of Acute Pyelonephritis | en |
| Type | Research Article | en |
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